Identification of anti-tumour biologics using primary tumour models, 3-D phenotypic screening and image-based multi-parametric profiling

BACKGROUND: Monolayer cultures of immortalised cell lines are a popular screening tool for novel anti-cancer therapeutics, but these methods can be a poor surrogate for disease states, and there is a need for drug screening platforms which are more predictive of clinical outcome. In this study, we d...

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Vydáno v:Mol Cancer
Hlavní autoři: Sandercock, Alan M., Rust, Steven, Guillard, Sandrine, Sachsenmeier, Kris F., Holoweckyj, Nick, Hay, Carl, Flynn, Matt, Huang, Qihui, Yan, Kuan, Herpers, Bram, Price, Leo S., Soden, Jo, Freeth, Jim, Jermutus, Lutz, Hollingsworth, Robert, Minter, Ralph
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4521473/
https://ncbi.nlm.nih.gov/pubmed/26227951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-015-0415-0
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