Identification of anti-tumour biologics using primary tumour models, 3-D phenotypic screening and image-based multi-parametric profiling

BACKGROUND: Monolayer cultures of immortalised cell lines are a popular screening tool for novel anti-cancer therapeutics, but these methods can be a poor surrogate for disease states, and there is a need for drug screening platforms which are more predictive of clinical outcome. In this study, we d...

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Veröffentlicht in:Mol Cancer
Hauptverfasser: Sandercock, Alan M., Rust, Steven, Guillard, Sandrine, Sachsenmeier, Kris F., Holoweckyj, Nick, Hay, Carl, Flynn, Matt, Huang, Qihui, Yan, Kuan, Herpers, Bram, Price, Leo S., Soden, Jo, Freeth, Jim, Jermutus, Lutz, Hollingsworth, Robert, Minter, Ralph
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4521473/
https://ncbi.nlm.nih.gov/pubmed/26227951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-015-0415-0
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