Reduced replication of 3TC-resistant HIV-1 variants in primary cells due to a processivity defect of the reverse transcriptase enzyme.

Human immunodeficiency virus type 1 (HIV-1) variants with resistance mutations in the reverse transcriptase (RT) gene appear during drug therapy with the nucleoside analogue 2',3'-dideoxy-3'-thiacytidine (3TC). These resistance mutations alter the methionine (Met) residue of the conse...

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Detalhes bibliográficos
Main Authors: Back, N K, Nijhuis, M, Keulen, W, Boucher, C A, Oude Essink, B O, van Kuilenburg, A B, van Gennip, A H, Berkhout, B
Formato: Artigo
Idioma:Inglês
Publicado em: 1996
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC452124/
https://ncbi.nlm.nih.gov/pubmed/8670908
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