Evidence That Antibiotics Bind to Human Mitochondrial Ribosomal RNA Has Implications for Aminoglycoside Toxicity

Aminoglycosides are a well known antibiotic family used to treat bacterial infections in humans and animals, but which can be toxic. By binding to the decoding site of helix44 of the small subunit RNA of the bacterial ribosome, the aminoglycoside antibiotics inhibit protein synthesis, cause misreadi...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Hong, Seoyeon, Harris, Kimberly A., Fanning, Kathryn D., Sarachan, Kathryn L., Frohlich, Kyla M., Agris, Paul F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4521047/
https://ncbi.nlm.nih.gov/pubmed/26060252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.655092
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