Evidence That Antibiotics Bind to Human Mitochondrial Ribosomal RNA Has Implications for Aminoglycoside Toxicity

Aminoglycosides are a well known antibiotic family used to treat bacterial infections in humans and animals, but which can be toxic. By binding to the decoding site of helix44 of the small subunit RNA of the bacterial ribosome, the aminoglycoside antibiotics inhibit protein synthesis, cause misreadi...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Hong, Seoyeon, Harris, Kimberly A., Fanning, Kathryn D., Sarachan, Kathryn L., Frohlich, Kyla M., Agris, Paul F.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2015
Matèries:
RNA
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4521047/
https://ncbi.nlm.nih.gov/pubmed/26060252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.655092
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