Deficiency of β Common Receptor Moderately Attenuates the Progression of Myeloproliferative Neoplasm in Nras(G12D/+) Mice

Activating Ras signaling is a major driver in juvenile and the myeloproliferative variant of chronic myelomonocytic leukemia (JMML/MP-CMML). Numerous studies suggest that GM-CSF signaling plays a central role in establishing and maintaining JMML/MP-CMML phenotypes in human and mouse. However, it rem...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Zhang, Jingfang, Ranheim, Erik A., Du, Juan, Liu, Yangang, Wang, Jinyong, Kong, Guangyao, Zhang, Jing
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2015
Teme:
Molecular Bases of Disease
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4521033/
https://ncbi.nlm.nih.gov/pubmed/26082490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.653154
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