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Deficiency of β Common Receptor Moderately Attenuates the Progression of Myeloproliferative Neoplasm in Nras(G12D/+) Mice
Activating Ras signaling is a major driver in juvenile and the myeloproliferative variant of chronic myelomonocytic leukemia (JMML/MP-CMML). Numerous studies suggest that GM-CSF signaling plays a central role in establishing and maintaining JMML/MP-CMML phenotypes in human and mouse. However, it rem...
Enregistré dans:
| Publié dans: | J Biol Chem |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4521033/ https://ncbi.nlm.nih.gov/pubmed/26082490 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.653154 |
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