Nitration of Hsp90 on Tyrosine 33 Regulates Mitochondrial Metabolism

Peroxynitrite production and tyrosine nitration are present in several pathological conditions, including neurodegeneration, stroke, aging, and cancer. Nitration of the pro-survival chaperone heat shock protein 90 (Hsp90) in position 33 and 56 induces motor neuron death through a toxic gain-of-funct...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Franco, Maria C., Ricart, Karina C., Gonzalez, Analía S., Dennys, Cassandra N., Nelson, Pascal A., Janes, Michael S., Mehl, Ryan A., Landar, Aimee, Estévez, Alvaro G.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2015
Teme:
Bioenergetics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4521030/
https://ncbi.nlm.nih.gov/pubmed/26085096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.663278
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