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Targeting HSP90 in ovarian cancers with multiple receptor tyrosine kinase coactivation

BACKGROUND: Ovarian cancer has the highest mortality rate of all gynecologic malignancy. The receptor tyrosine kinases (RTKs), including EGFR, ERBB2, PDGFR, VEGFR and MET, are activated in subsets of ovarian cancer, suggesting that these kinases might represent novel therapeutic targets. However, cl...

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Detalhes bibliográficos
Main Authors: Jiao, Yisheng, Ou, Wenbin, Meng, Fanguo, Zhou, Haimeng, Wang, Aiyuan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196924/
https://ncbi.nlm.nih.gov/pubmed/21962244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-10-125
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