Targeting HSP90 in ovarian cancers with multiple receptor tyrosine kinase coactivation

BACKGROUND: Ovarian cancer has the highest mortality rate of all gynecologic malignancy. The receptor tyrosine kinases (RTKs), including EGFR, ERBB2, PDGFR, VEGFR and MET, are activated in subsets of ovarian cancer, suggesting that these kinases might represent novel therapeutic targets. However, cl...

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Bibliographic Details
Main Authors: Jiao, Yisheng, Ou, Wenbin, Meng, Fanguo, Zhou, Haimeng, Wang, Aiyuan
Format: Artigo
Language:Inglês
Published: BioMed Central 2011
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196924/
https://ncbi.nlm.nih.gov/pubmed/21962244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-10-125
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