The Inhibitory Core of the Myostatin Prodomain: Its Interaction with Both Type I and II Membrane Receptors, and Potential to Treat Muscle Atrophy

Myostatin, a muscle-specific transforming growth factor-β (TGF-β), negatively regulates skeletal muscle mass. The N-terminal prodomain of myostatin noncovalently binds to and suppresses the C-terminal mature domain (ligand) as an inactive circulating complex. However, which region of the myostatin p...

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Veröffentlicht in:PLoS One
Hauptverfasser: Ohsawa, Yutaka, Takayama, Kentaro, Nishimatsu, Shin-ichiro, Okada, Tadashi, Fujino, Masahiro, Fukai, Yuta, Murakami, Tatsufumi, Hagiwara, Hiroki, Itoh, Fumiko, Tsuchida, Kunihiro, Hayashi, Yoshio, Sunada, Yoshihide
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4520684/
https://ncbi.nlm.nih.gov/pubmed/26226340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0133713
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