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Virtual Screening of Peptide and Peptidomimetic Fragments Targeted to Inhibit Bacterial Dithiol Oxidase DsbA

Antibacterial drugs with novel scaffolds and new mechanisms of action are desperately needed to address the growing problem of antibiotic resistance. The periplasmic oxidative folding system in Gram-negative bacteria represents a possible target for anti-virulence antibacterials. By targeting virule...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Duprez, Wilko, Bachu, Prabhakar, Stoermer, Martin J., Tay, Stephanie, McMahon, Róisín M., Fairlie, David P., Martin, Jennifer L.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4520593/
https://ncbi.nlm.nih.gov/pubmed/26225423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0133805
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