Intrinsic signaling function of APP as a novel target of three V642 mutations linked to familial Alzheimer's disease.

APP695 is a transmembrane precursor of Abeta amyloid. In familial Alzheimer's disease (FAD), three mutations V642I/F/G were discovered in APP695, which has been suggested by multiple studies to be a cell surface signaling receptor. We previously reported that normal APP695 encodes a potential G...

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Veröffentlicht in:EMBO J
Hauptverfasser: Okamoto, T, Takeda, S, Giambarella, U, Murayama, Y, Matsui, T, Katada, T, Matsuura, Y, Nishimoto, I
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 1996
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC452057/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8670881/
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