GBM Derived Gangliosides Induce T Cell Apoptosis through Activation of the Caspase Cascade Involving Both the Extrinsic and the Intrinsic Pathway

Previously we demonstrated that human glioblastoma cell lines induce apoptosis in peripheral blood T cells through partial involvement of secreted gangliosides. Here we show that GBM-derived gangliosides induce apoptosis through involvement of the TNF receptor and activation of the caspase cascade....

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Mahata, Barun, Biswas, Soumika, Rayman, Patricia, Chahlavi, Ali, Ko, Jennifer, Bhattacharjee, Ashish, Li, Yu-Teh, Li, Yuntao, Das, Tanya, Sa, Gaurisankar, Raychaudhuri, Baisakhi, Vogelbaum, Michael A., Tannenbaum, Charles, Finke, James H., Biswas, Kaushik
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4520498/
https://ncbi.nlm.nih.gov/pubmed/26226135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0134425
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