TALEN mediated targeted editing of GM2/GD2-synthase gene modulates anchorage independent growth by reducing anoikis resistance in mouse tumor cells

Complex ganglioside expression is highly deregulated in several tumors which is further dependent on specific ganglioside synthase genes. Here, we designed and constructed a pair of highly specific transcription-activator like effector endonuclease (TALENs) to disrupt a particular genomic locus of m...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Mahata, Barun, Banerjee, Avisek, Kundu, Manjari, Bandyopadhyay, Uday, Biswas, Kaushik
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4357006/
https://ncbi.nlm.nih.gov/pubmed/25762467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep09048
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