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Identification and characterization of a novel ISG15-ubiquitin mixed chain and its role in regulating protein homeostasis
As a ubiquitin-like modifier, ISG15 is conjugated to many cellular proteins in a process termed protein ISGylation. However, the crosstalk between protein ISGylation and the ubiquitin proteasome system is not fully understood. Here, we report that cellular ubiquitin is a substrate of ISG15 and Lys 2...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4520236/ https://ncbi.nlm.nih.gov/pubmed/26226047 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12704 |
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