Baicalin Protects Mice from Aristolochic Acid I-Induced Kidney Injury by Induction of CYP1A through the Aromatic Hydrocarbon Receptor

Exposure to aristolochic acid I (AAI) can lead to aristolochic acid nephropathy (AAN), Balkan endemic nephropathy (BEN) and urothelial cancer. The induction of hepatic CYP1A, especially CYP1A2, was considered to detoxify AAI so as to reduce its nephrotoxicity. We previously found that baicalin had t...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Wang, Ke, Feng, Chenchen, Li, Chenggang, Yao, Jun, Xie, Xiaofeng, Gong, Likun, Luan, Yang, Xing, Guozhen, Zhu, Xue, Qi, Xinming, Ren, Jin
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4519959/
https://ncbi.nlm.nih.gov/pubmed/26204831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms160716454
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