Mitochondrial biogenesis is impaired in osteoarthritic chondrocytes but reversible via peroxisome proliferator-activated receptor-γ coactivator 1α

OBJECTIVE: The etiology of chondrocyte mitochondrial dysfunction in OA is incompletely understood. OA chondrocytes are deficient in active AMPK-activated protein kinase (AMPK) and sirtuin 1 (SIRT1), metabolic biosensors that modulate the mitochondrial biogenesis “master regulator” peroxisome prolife...

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Bibliographic Details
Published in:Arthritis Rheumatol
Main Authors: Wang, Yun, Zhao, Xianling, Lotz, Martin, Terkeltaub, Robert, Liu-Bryan, Ru
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4519411/
https://ncbi.nlm.nih.gov/pubmed/25940958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.39182
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