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Mitochondrial biogenesis is impaired in osteoarthritic chondrocytes but reversible via peroxisome proliferator-activated receptor-γ coactivator 1α
OBJECTIVE: The etiology of chondrocyte mitochondrial dysfunction in OA is incompletely understood. OA chondrocytes are deficient in active AMPK-activated protein kinase (AMPK) and sirtuin 1 (SIRT1), metabolic biosensors that modulate the mitochondrial biogenesis “master regulator” peroxisome prolife...
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| Published in: | Arthritis Rheumatol |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2015
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4519411/ https://ncbi.nlm.nih.gov/pubmed/25940958 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.39182 |
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