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Peroxisome Proliferator–Activated Receptor γ Coactivator 1α and FoxO3A Mediate Chondroprotection by AMP-Activated Protein Kinase
OBJECTIVE: AMP-activated protein kinase (AMPK) inhibits chondrocyte procatabolic responses to inflammation and biomechanical injury. This study was undertaken to test the hypothesis that peroxisome proliferator–activated receptor γ coactivator 1α (PGC-1α) and FoxO3A, 2 major AMPK downstream targets,...
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| Publicado no: | Arthritis Rheumatol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4343036/ https://ncbi.nlm.nih.gov/pubmed/25047750 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.38791 |
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