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AMP-activated protein kinase suppresses urate crystal-induced inflammation and transduces colchicine effects in macrophages
OBJECTIVE: AMP-activated protein kinase (AMPK) is metabolic biosensor with anti-inflammatory activities. Gout is commonly associated with excesses in soluble urate and in nutrition, both of which suppress tissue AMPK activity. Gout is driven by macrophage-mediated inflammation transduced partly by N...
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| Publicado no: | Ann Rheum Dis |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4417082/ https://ncbi.nlm.nih.gov/pubmed/25362043 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2014-206074 |
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