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AMP-activated protein kinase suppresses urate crystal-induced inflammation and transduces colchicine effects in macrophages

OBJECTIVE: AMP-activated protein kinase (AMPK) is metabolic biosensor with anti-inflammatory activities. Gout is commonly associated with excesses in soluble urate and in nutrition, both of which suppress tissue AMPK activity. Gout is driven by macrophage-mediated inflammation transduced partly by N...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Ann Rheum Dis
Prif Awduron: Wang, Yun, Viollet, Benoit, Terkeltaub, Robert, Liu-Bryan, Ru
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4417082/
https://ncbi.nlm.nih.gov/pubmed/25362043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2014-206074
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