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Identification of contacts between topoisomerase I and its target DNA by site-specific photocrosslinking.

Vaccinia DNA topoisomerase, a eukaryotic type I enzyme, binds and cleaves duplex DNA at sites containing the sequence 5'-(T/C)CCTT. We report the identification of Tyr70 as the site of contact between the enzyme and the +4C base of its target site. This was accomplished by UV-crosslinking topoi...

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Detalles Bibliográficos
Publicado en:EMBO J
Autores principales: Sekiguchi, J, Shuman, S
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 1996
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Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC451909/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8670847/
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