Use of Fc-Engineered Antibodies as Clearing Agents to Increase Contrast During PET

Despite promise for the use of antibodies as molecular imaging agents in PET, their long in vivo half-lives result in poor contrast and radiation damage to normal tissue. This study describes an approach to overcome these limitations. METHODS: Mice bearing human epidermal growth factor receptor type...

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Detalhes bibliográficos
Publicado no:J Nucl Med
Main Authors: Swiercz, Rafal, Chiguru, Srinivas, Tahmasbi, Amir, Ramezani, Saleh M., Hao, Guiyang, Challa, Dilip K., Lewis, Matthew A., Kulkarni, Padmakar V., Sun, Xiankai, Ober, Raimund J., Mason, Ralph P., Ward, E. Sally
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4519079/
https://ncbi.nlm.nih.gov/pubmed/24868106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.113.136481
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