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Stable binding of the herpes simplex virus ICP47 protein to the peptide binding site of TAP.

The herpes simplex virus (HSV) ICP47 protein inhibits the MHC class I antigen presentation pathway by inhibiting the transporter associated with antigen presentation (TAP) which translocates peptides across the endoplasmic reticulum membrane. At present, ICP47 is the only inhibitor of TAP. Here, we...

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書誌詳細
主要な著者: Tomazin, R, Hill, A B, Jugovic, P, York, I, van Endert, P, Ploegh, H L, Andrews, D W, Johnson, D C
フォーマット: Artigo
言語:Inglês
出版事項: 1996
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC451888/
https://ncbi.nlm.nih.gov/pubmed/8670826
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