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Stable binding of the herpes simplex virus ICP47 protein to the peptide binding site of TAP.

The herpes simplex virus (HSV) ICP47 protein inhibits the MHC class I antigen presentation pathway by inhibiting the transporter associated with antigen presentation (TAP) which translocates peptides across the endoplasmic reticulum membrane. At present, ICP47 is the only inhibitor of TAP. Here, we...

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Udgivet i:EMBO J
Principais autores: Tomazin, R, Hill, A B, Jugovic, P, York, I, van Endert, P, Ploegh, H L, Andrews, D W, Johnson, D C
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC451888/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8670826/
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