STIM1 controls T cell–mediated immune regulation and inflammation in chronic infection

Chronic infections induce a complex immune response that controls pathogen replication, but also causes pathology due to sustained inflammation. Ca(2+) influx mediates T cell function and immunity to infection, and patients with inherited mutations in the gene encoding the Ca(2+) channel ORAI1 or it...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Desvignes, Ludovic, Weidinger, Carl, Shaw, Patrick, Vaeth, Martin, Ribierre, Theo, Liu, Menghan, Fergus, Tawania, Kozhaya, Lina, McVoy, Lauren, Unutmaz, Derya, Ernst, Joel D., Feske, Stefan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2015
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4518689/
https://ncbi.nlm.nih.gov/pubmed/25938788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI80273
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