Recombinant IgG2a Fc (M045(1)) Multimers Effectively Suppress Experimental Autoimmune Myasthenia Gravis

Myasthenia gravis (MG) is an autoimmune disorder caused by target-specific pathogenic antibodies directed toward postsynaptic neuromuscular junction (NMJ) proteins, most commonly the skeletal muscle nicotinic acetylcholine receptor (AChR). In MG, high-affinity anti-AChR Abs binding to the NMJ lead t...

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Udgivet i:J Autoimmun
Main Authors: Thiruppathi, Muthusamy, Sheng, Jian Rong, Li, Liangcheng, Prabhakar, Bellur S., Meriggioli, Matthew N.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4518541/
https://ncbi.nlm.nih.gov/pubmed/24388113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2013.12.014
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