The Ras-Erk-ETS-Signaling Pathway Is a Drug Target for Longevity

Identifying the molecular mechanisms that underlie aging and their pharmacological manipulation are key aims for improving lifelong human health. Here, we identify a critical role for Ras-Erk-ETS signaling in aging in Drosophila. We show that inhibition of Ras is sufficient for lifespan extension do...

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Bibliografske podrobnosti
izdano v:Cell
Main Authors: Slack, Cathy, Alic, Nazif, Foley, Andrea, Cabecinha, Melissa, Hoddinott, Matthew P., Partridge, Linda
Format: Artigo
Jezik:Inglês
Izdano: Cell Press 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4518474/
https://ncbi.nlm.nih.gov/pubmed/26119340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.06.023
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