Development of 6H-Chromeno[3,4-c]pyrido[3',2':4,5]thieno[2,3-e]pyridazin-6-ones as Par-4 Secretagogues

Nitrosation and cyclization of 4-(3-aminothieno[2,3-b]pyridine-2-yl)-2H-chromen-2-ones 1 afforded substituted 6H-chromeno[3,4-c]pyrido[3',2':4,5]thieno[2,3-e]pyridazin-6-ones 2 that inhibited the intermediary filament protein, vimentin, at low micromolar concentrations. This inhibition pro...

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Publicado en:Tetrahedron Lett
Autores principales: Frasinyuk, Mykhaylo S., Bondarenko, Svitlana P., Sviripa, Vitaliy M., Burikhanov, Ravshan, Rangnekar, Vivek M., Liu, Chunming, Watt, David S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4518469/
https://ncbi.nlm.nih.gov/pubmed/26236052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2015.01.028
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