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Three missense variants of metabolic syndrome-related genes are associated with alpha-1 antitrypsin levels

Alpha-1 antitrypsin (AAT) encoded by SERPINA1 is an acute-phase inflammation marker, and AAT deficiency (AATD) is known as one of the common genetic disorders in European populations. However, no genetic determinants to AAT levels apart from the SERPINA gene clusters have been identified to date. He...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Setoh, Kazuya, Terao, Chikashi, Muro, Shigeo, Kawaguchi, Takahisa, Tabara, Yasuharu, Takahashi, Meiko, Nakayama, Takeo, Kosugi, Shinji, Sekine, Akihiro, Yamada, Ryo, Mishima, Michiaki, Matsuda, Fumihiko
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4518310/
https://ncbi.nlm.nih.gov/pubmed/26174136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8754
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