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Study of the Binding Energies between Unnatural Amino Acids and Engineered Orthogonal Tyrosyl-tRNA Synthetases

We utilized several computational approaches to evaluate the binding energies of tyrosine (Tyr) and several unnatural Tyr analogs, to several orthogonal aaRSes derived from Methanocaldococcus jannaschii and Escherichia coli tyrosyl-tRNA synthetases. The present study reveals the following: (1) AutoD...

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Foilsithe in:Sci Rep
Main Authors: Ren, Wei, Truong, Tan M., Ai, Hui-wang
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2015
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4518261/
https://ncbi.nlm.nih.gov/pubmed/26220470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12632
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