LK6/Mnk2a is a new kinase of alpha synuclein phosphorylation mediating neurodegeneration

Parkinson’s disease (PD) is a movement disorder due to the loss of dopaminergic (DA) neurons in the substantia nigra. Alpha-synuclein phosphorylation and α-synuclein inclusion (Lewy body) become a main contributor, but little is known about their formation mechanism. Here we used protein expression...

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Vydáno v:Sci Rep
Hlavní autoři: Zhang, Shiqing, Xie, Jiang, Xia, Ying, Yu, Shu, Gu, Zhili, Feng, Ruili, Luo, Guanghong, Wang, Dong, Wang, Kai, Jiang, Meng, Cheng, Xiao, Huang, Hai, Zhang, Wu, Wen, Tieqiao
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4518213/
https://ncbi.nlm.nih.gov/pubmed/26220523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12564
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