Interrogating alkyl and arylalkylpolyamino (bis)urea and (bis)thiourea isosteres as potent antimalarial chemotypes against multiple lifecycle forms of Plasmodium falciparum parasites

A new series of potent potent aryl/alkylated (bis)urea- and (bis)thiourea polyamine analogues were synthesized and evaluated in vitro for their antiplasmodial activity. Altering the carbon backbone and terminal substituents increased the potency of analogues in the compound library 3-fold, with the...

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Bibliografske podrobnosti
izdano v:Bioorg Med Chem
Main Authors: Verlinden, Bianca K., de Beer, Marna, Pachaiyappan, Boobalan, Besaans, Ethan, Andayi, Warren A., Reader, Janette, Niemand, Jandeli, van Biljon, Riette, Guy, Kiplin, Egan, Timothy, Woster, Patrick M., Birkholtz, Lyn-Marie
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4517987/
https://ncbi.nlm.nih.gov/pubmed/25684422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.01.036
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