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Checkpoint Activation of an Unconventional DNA Replication Program in Tetrahymena

The intra-S phase checkpoint kinase of metazoa and yeast, ATR/MEC1, protects chromosomes from DNA damage and replication stress by phosphorylating subunits of the replicative helicase, MCM2-7. Here we describe an unprecedented ATR-dependent pathway in Tetrahymena thermophila in which the essential p...

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Publicado en:PLoS Genet
Autores principales: Sandoval, Pamela Y., Lee, Po-Hsuen, Meng, Xiangzhou, Kapler, Geoffrey M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4517752/
https://ncbi.nlm.nih.gov/pubmed/26218270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005405
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