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Checkpoint Activation of an Unconventional DNA Replication Program in Tetrahymena
The intra-S phase checkpoint kinase of metazoa and yeast, ATR/MEC1, protects chromosomes from DNA damage and replication stress by phosphorylating subunits of the replicative helicase, MCM2-7. Here we describe an unprecedented ATR-dependent pathway in Tetrahymena thermophila in which the essential p...
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| Publicado no: | PLoS Genet |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4517752/ https://ncbi.nlm.nih.gov/pubmed/26218270 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005405 |
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