Checkpoint Activation of an Unconventional DNA Replication Program in Tetrahymena

The intra-S phase checkpoint kinase of metazoa and yeast, ATR/MEC1, protects chromosomes from DNA damage and replication stress by phosphorylating subunits of the replicative helicase, MCM2-7. Here we describe an unprecedented ATR-dependent pathway in Tetrahymena thermophila in which the essential p...

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Bibliografske podrobnosti
izdano v:PLoS Genet
Main Authors: Sandoval, Pamela Y., Lee, Po-Hsuen, Meng, Xiangzhou, Kapler, Geoffrey M.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4517752/
https://ncbi.nlm.nih.gov/pubmed/26218270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005405
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