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Jagged mediates differences in normal and tumor angiogenesis by affecting tip-stalk fate decision

Angiogenesis is critical during development, wound repair, and cancer progression. During angiogenesis, some endothelial cells adopt a tip phenotype to lead the formation of new branching vessels; the trailing stalk cells proliferate to develop the vessel. Notch and VEGF signaling mediate the select...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Boareto, Marcelo, Jolly, Mohit Kumar, Ben-Jacob, Eshel, Onuchic, José N.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4517227/
https://ncbi.nlm.nih.gov/pubmed/26153421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1511814112
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