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Heparin enhances uptake of platelet factor 4/heparin complexes by monocytes and macrophages
BACKGROUND: Heparin-induced thrombocytopenia (HIT) is an iatrogenic complication of heparin therapy caused by antibodies to a self-antigen, platelet factor (4) and heparin. The reasons why antibodies form to PF4/heparin, but not to PF4 bound to other cellular glycosaminoglycans are poorly understood...
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| Publicado en: | J Thromb Haemost |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4516590/ https://ncbi.nlm.nih.gov/pubmed/25960020 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.13003 |
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