Targeting a unique EGFR epitope with monoclonal antibody 806 activates NF-κB and initiates tumour vascular normalization

Monoclonal antibodies (mAbs) and tyrosine kinase inhibitors targeting the epidermal growth factor receptor (EGFR), which is often pathogenetically overexpressed or mutated in epithelial malignancies and glioma, have been modestly successful, with some approved for human use. MAb 806 was raised again...

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Foilsithe in:J Cell Mol Med
Main Authors: Gan, Hui K, Lappas, Martha, Cao, Diana X, Cvrljevdic, Anna, Scott, Andrew M, Johns, Terrance G
Formáid: Artigo
Teanga:Inglês
Foilsithe: John Wiley & Sons, Ltd 2009
Ábhair:
Molecular Oncology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4516546/
https://ncbi.nlm.nih.gov/pubmed/19432811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2009.00783.x
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