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Ethics, Error, and Initial Trials of Efficacy

Concerns about the frequency of failure in late stage drug development have prompted a series of proposals for improving the positive predictivity of trials where clinical activity is first evaluated—typically phase 2 trials. However, many proposed reforms entail ethical and social tradeoffs that mi...

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Publicat a:Sci Transl Med
Autors principals: Hey, Spencer Phillips, Kimmelman, Jonathan
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4516405/
https://ncbi.nlm.nih.gov/pubmed/23658242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3005684
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