Effects of MEK inhibitors GSK1120212 and PD0325901 in vivo using 10-plex quantitative proteomics and phosphoproteomics

Multiplexed isobaric tag-based quantitative proteomics and phosphoproteomics strategies can comprehensively analyze drug treatments effects on biological systems. Given the role of MEK signaling in cancer and MAPK-dependent diseases, we sought to determine if this pathway could be inhibited safely b...

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Vydáno v:Proteomics
Hlavní autoři: Paulo, Joao A., McAllister, Fiona E., Everley, Robert A., Beausoleil, Sean A., Banks, Alexander S., Gygi, Steven P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4515953/
https://ncbi.nlm.nih.gov/pubmed/25195567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pmic.201400154
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