C-Jun N-terminal kinases are required for oncolytic adenovirus-mediated autophagy

Oncolytic adenoviruses, such as Delta-24-RGD, are replication-competent viruses that are genetically engineered to induce selective cancer cell lysis. In cancer cells, Delta-24-RGD induces massive autophagy, which is required for efficient cell lysis and adenoviral spread. Understanding the cellular...

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Foilsithe in:Oncogene
Main Authors: Klein, SR, Piya, S, Lu, Z, Xia, Y, Alonso, MM, White, EJ, Wei, J, Gomez-Manzano, C, Jiang, H, Fueyo, J
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2015
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4515398/
https://ncbi.nlm.nih.gov/pubmed/25619840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.452
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