The activation of c-Jun NH(2)-terminal kinase is required for dihydroartemisinin-induced autophagy in pancreatic cancer cells

BACKGROUND: c-Jun NH2-terminal kinases (JNKs) are strongly activated by a stressful cellular environment, such as chemotherapy and oxidative stress. Autophagy is a protein-degradation system in which double-membrane vacuoles called autophagosomes are formed. The autophagy-related gene Beclin 1 plays...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Jia, Guang, Kong, Rui, Ma, Zhi-Bin, Han, Bing, Wang, Yong-Wei, Pan, Shang-Ha, Li, Ying-Hua, Sun, Bei
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2014
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3901759/
https://ncbi.nlm.nih.gov/pubmed/24438216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-9966-33-8
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