Phase 1 pharmacokinetic study of the oral pan-AKT inhibitor MK-2206 in Japanese patients with advanced solid tumors

PURPOSE: MK-2206 is an oral, highly selective inhibitor of AKT. The safety, tolerability, pharmacokinetics (PK), and anti-tumor activity of MK-2206 was evaluated in Japanese patients with advanced solid tumors. METHODS: Patients received a single oral dose of MK-2206 according to an every other day...

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Библиографические подробности
Опубликовано в: :Cancer Chemother Pharmacol
Главные авторы: Doi, Toshihiko, Tamura, Kenji, Tanabe, Yuko, Yonemori, Kan, Yoshino, Takayuki, Fuse, Nozomu, Kodaira, Makoto, Bando, Hideaki, Noguchi, Kazuo, Shimamoto, Takashi, Ohtsu, Atsushi
Формат: Artigo
Язык:Inglês
Опубликовано: Springer Berlin Heidelberg 2015
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4515243/
https://ncbi.nlm.nih.gov/pubmed/26104654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-015-2810-z
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