Expression of the IL-11 Gene in Metastatic Cells Is Supported by Runx2-Smad and Runx2-cJun Complexes Induced by TGFβ1

In tumor cells, two factors are abnormally increased that contribute to metastatic bone disease: Runx2, a transcription factor that promotes expression of metastasis related and osteolytic genes; and IL-11, a secreted osteolytic cytokine. Here, we addressed a compelling question: Does Runx2 regulate...

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Pubblicato in:J Cell Biochem
Autori principali: Zhang, Xuhui, Wu, Hai, Dobson, Jason R., Browne, Gillian, Hong, Deli, Akech, Jacqueline, Languino, Lucia R., Stein, Janet L., Stein, Gary S., Lian, Jane B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4515199/
https://ncbi.nlm.nih.gov/pubmed/25808168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.25167
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