Systemic and mucosal immunity in mice elicited by a single immunization with human adenovirus type 5 or 41 vector-based vaccines carrying the spike protein of Middle East respiratory syndrome coronavirus

An ideal vaccine against mucosal pathogens such as Middle East respiratory syndrome coronavirus (MERS-CoV) should confer sustained, protective immunity at both systemic and mucosal levels. Here, we evaluated the in vivo systemic and mucosal antigen-specific immune responses induced by a single intra...

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Vydáno v:Immunology
Hlavní autoři: Guo, Xiaojuan, Deng, Yao, Chen, Hong, Lan, Jiaming, Wang, Wen, Zou, Xiaohui, Hung, Tao, Lu, Zhuozhuang, Tan, Wenjie
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley & Sons, Ltd 2015
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4515128/
https://ncbi.nlm.nih.gov/pubmed/25762305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.12462
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