Enhanced protection in mice induced by immunization with inactivated whole viruses compare to spike protein of middle east respiratory syndrome coronavirus

The persistent public health threat of infection with Middle East respiratory syndrome coronavirus (MERS-CoV) highlights the need for an effective and safe MERS-CoV vaccine. In this study, we prepared and vaccinated mice with either a Spike (S) protein or inactivated whole MERS-CoV (IV) with a combi...

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Bibliografiske detaljer
Udgivet i:Emerg Microbes Infect
Main Authors: Deng, Yao, Lan, Jiaming, Bao, Linlin, Huang, Baoying, Ye, Fei, Chen, Yingzhu, Yao, Yanfeng, Wang, Wenling, Qin, Chuan, Tan, Wenjie
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5884803/
https://ncbi.nlm.nih.gov/pubmed/29618723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41426-018-0056-7
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