D2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH2

Isocitrate dehydrogenases (IDH) convert isocitrate to alpha-ketoglutarate (α-KG). In cancer, mutant IDH1/2 reduces α-KG to D2-hydroxyglutarate (D2-HG) disrupting α-KG-dependent dioxygenases. However, the physiological relevance of controlling the interconversion of D2-HG into α-KG, mediated by D2-hy...

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Publicado en:Nat Commun
Autores principales: Lin, An-Ping, Abbas, Saman, Kim, Sang-Woo, Ortega, Manoela, Bouamar, Hakim, Escobedo, Yissela, Varadarajan, Prakash, Qin, Yuejuan, Sudderth, Jessica, Schulz, Eduard, Deutsch, Alexander, Mohan, Sumitra, Ulz, Peter, Neumeister, Peter, Rakheja, Dinesh, Gao, Xiaoli, Hinck, Andrew, Weintraub, Susan T., DeBerardinis, Ralph J., Sill, Heinz, Dahia, Patricia L. M., Aguiar, Ricardo C. T.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Pub. Group 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4515030/
https://ncbi.nlm.nih.gov/pubmed/26178471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8768
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