Chlamydia trachomatis In Vivo to In Vitro Transition Reveals Mechanisms of Phase Variation and Down-Regulation of Virulence Factors

Research on the obligate intracellular bacterium Chlamydia trachomatis demands culture in cell-lines, but the adaptive process behind the in vivo to in vitro transition is not understood. We assessed the genomic and transcriptomic dynamics underlying C. trachomatis in vitro adaptation of strains rep...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Borges, Vítor, Pinheiro, Miguel, Antelo, Minia, Sampaio, Daniel A., Vieira, Luís, Ferreira, Rita, Nunes, Alexandra, Almeida, Filipe, Mota, Luís J., Borrego, Maria J., Gomes, João P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4514472/
https://ncbi.nlm.nih.gov/pubmed/26207372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0133420
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