Chlamydia trachomatis In Vivo to In Vitro Transition Reveals Mechanisms of Phase Variation and Down-Regulation of Virulence Factors

Research on the obligate intracellular bacterium Chlamydia trachomatis demands culture in cell-lines, but the adaptive process behind the in vivo to in vitro transition is not understood. We assessed the genomic and transcriptomic dynamics underlying C. trachomatis in vitro adaptation of strains rep...

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Pubblicato in:PLoS One
Autori principali: Borges, Vítor, Pinheiro, Miguel, Antelo, Minia, Sampaio, Daniel A., Vieira, Luís, Ferreira, Rita, Nunes, Alexandra, Almeida, Filipe, Mota, Luís J., Borrego, Maria J., Gomes, João P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4514472/
https://ncbi.nlm.nih.gov/pubmed/26207372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0133420
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