Development of a heat-stable and orally delivered recombinant M2e-expressing B. subtilis spore-based influenza vaccine

Highly conserved ectodomain of influenza virus M2 protein (M2e) is an important target for the development of universal influenza vaccines. Today, the use of chemical or genetic fusion constructs have been undertaken to overcome the low immunogenicity of M2e in vaccine formulation. However, current...

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Detalhes bibliográficos
Publicado no:Hum Vaccin Immunother
Main Authors: Zhao, Guangyu, Miao, Yu, Guo, Yan, Qiu, Hongjie, Sun, Shihui, Kou, Zhihua, Yu, Hong, Li, Junfeng, Chen, Yue, Jiang, Shibo, Du, Lanying, Zhou, Yusen
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2014
Assuntos:
INFLUENZA/Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4514050/
https://ncbi.nlm.nih.gov/pubmed/25483702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/hv.36122
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