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Cooperative Electrostatic Interactions Drive Functional Evolution in the Alkaline Phosphatase Superfamily
[Image: see text] It is becoming widely accepted that catalytic promiscuity, i.e., the ability of a single enzyme to catalyze the turnover of multiple, chemically distinct substrates, plays a key role in the evolution of new enzyme functions. In this context, the members of the alkaline phosphatase...
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| Udgivet i: | J Am Chem Soc |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Chemical
Society
2015
|
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4513756/ https://ncbi.nlm.nih.gov/pubmed/26091851 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b03945 |
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